|
Symbol Name ID |
Mpl
myeloproliferative leukemia virus oncogene MGI:97076 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Abnormal bleeding |
Epistaxis |
Joint hemorrhage |
Persistent bleeding after trauma |
Prolonged bleeding time |
Bruising susceptibility |
Purpura |
Petechiae |
Abnormal bone marrow cell morphology |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Increased megakaryocyte count |
Increased micromegakaryocyte count |
Increased multinucleated megakaryocyte count |
Megakaryocyte nucleus hyperlobulation |
Myelofibrosis |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Hemophagocytosis |
Acute leukemia |
Acute myeloid leukemia |
Chronic myelogenous leukemia |
Myeloproliferative disorder |
Arterial thrombosis |
Venous thrombosis |
Hepatic vein thrombosis |
Abnormality of thrombocytes |
Impaired ADP-induced platelet aggregation |
Impaired collagen-induced platelet aggregation |
Impaired epinephrine-induced platelet aggregation |
Abnormal platelet morphology |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Thrombocytosis |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Extramedullary hematopoiesis |
Myelodysplasia |
Splenomegaly |
| Disease(s) Associated with MPL | |||||||||||||||||||||||||||||||||||||||||||||
| essential thrombocythemia | |||||||||||||||||||||||||||||||||||||||||||||
| myelofibrosis | |||||||||||||||||||||||||||||||||||||||||||||
| thrombocytopenia |
| Mouse Phenotypes | increased hematopoietic stem cell proliferation |
enlarged spleen |
abnormal definitive hematopoiesis |
abnormal common myeloid progenitor cell morphology |
decreased common myeloid progenitor cell number |
anemia |
abnormal megakaryocyte morphology |
decreased megakaryocyte cell number |
absent megakaryocytes |
increased megakaryocyte cell number |
decreased erythroid progenitor cell number |
abnormal megakaryocyte progenitor cell morphology |
decreased erythrocyte cell number |
decreased hematocrit |
decreased hemoglobin content |
thrombocytopenia |
thrombocytosis |
increased mean platelet volume |
decreased leukocyte cell number |
decreased hematopoietic stem cell number |
|
| Availability | Mouse Genotype | ||||||||||||||||||||
| Mplhlb219/Mplhlb219 | |||||||||||||||||||||
| Mpltm1Fjs/Mpltm1Fjs | |||||||||||||||||||||
| Mpltm1Mwm/Mpltm1Mwm | |||||||||||||||||||||
| Mpltm1Wsa/Mpltm1Wsa | |||||||||||||||||||||
| Mpltm2.2Wsa/Mpltm2.2Wsa | |||||||||||||||||||||
| Mplhlb219/Mpl+ | |||||||||||||||||||||
| Mpltm2.1Wsa/Mpltm2.1Wsa Tg(Pf4-icre)Q3Rsko/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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